Are there direct flights from Tocumen (PTY) to Guayaquil (GYE)?

Yes. 5 direct route option(s) are currently listed for PTY to GYE.

Are one-stop or two-stop connections available from Tocumen to Guayaquil?

No connecting itineraries are currently listed in this dataset.

Route intelligence for PTY → GYE: direct flights, stopover options, and timetable coverage in one place.

5 direct option(s) across 5 airline(s) · 1,250 km route distance.

Open each airline route-map page to compare broader network depth before committing to a nonstop or one-stop strategy.

Published flight numbers: CM258, UA7106, CM213, KL3009, UA7087, AF5529, KL3012, TK9636, UA7165, AF4515, TK9642

Flight number: CM 258

Operating days: 2, 4

Compare nearby alternatives and airline networks to decide whether a direct trip, one-stop connection, or reverse search gives you better options.

Compare direct duration with one-stop total duration before committing to a fare.
Check inbound alternatives on flights to GYE when return timing is important.
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